Scheme 1. Synthesis of Compound 2.
Reagents and conditions. a. Cs2CO3, DMSO, 120°C, 18 h. b. H-cube. c. Pd2dba3, RuPhos, Cs2CO3, THF, 80°C, 18 h. d. 4 N HCl/dioxane, MeOH, RT, 1h. e. Crystallization in IPA. f. Ambersep900OH, MeOH, rt, 1 h.
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