. 2023 Jul 31;14(8):1054–1062. doi: 10.1021/acsmedchemlett.3c00136

Table 2. Profiling Data of Compounds 2, 11–22^a.

graphic file with name ml3c00136_0009.jpg

Potency in cellular assays for TLR7, TLR8, and TLR9 (PBMCs) as described in the Supporting Information. IC₅₀ in μM ± geomeans; numbers in brackets denote number of independent experiments. HT solubility and CYP3A4 inhibition (μM), TDI: Kobs (min^–1), hERG: ³H-dofetilite displacement assay (μM). Metabolic clearance: CL_int (μL/min/mg). ND = not determined.

Table 2. Profiling Data of Compounds 2, 11–22a.

Table 2. Profiling Data of Compounds 2, 11–22^a.