Table 3.

Replicated MR analysis by IVW method after removing confounders-related IVs

Exposure	Outcome	P value	OR(95%CI)
Family	IVDD
Family Rikenellaceae id.967		0.069	0.903(0.809–1.008)
Family Ruminococcaceae id.2050		0.005	0.813(0.705–0.939)
Genus
Genus Escherichia Shigella id.3504		0.019	1.163(1.025–1.319)
Genus Eubacterium coprostanoligenes group id.11375		0.001	0.801(0.704–0.912)
Genus Gordonibacter id.821		0.028	0.933(0.877–0.993)
Genus Lachnoclostridium id.11308		0.075	0.885(0.774–1.012)
Genus Marvinbryantia id.2005		0.010	1.176(1.039–1.330)
Genus Oscillospira id.2064		0.058	0.885(0.779–1.004)
Phylum
Phylum Bacteroidetes id.905		0.004	1.218(1.065–1.392)