Table 1.
Circulating levels of biomarkers of interest according to case–control status among postmenopausal females, the Multiethnic Cohort
| Biomarkers of interest | Matched pairs | Controls | Breast cancer cases | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Mean | SD | Min | Max | Mean | SD | Min | Max | |
| 27HC (ng/mL) | 1470 | 83.89 | 22.45 | 33.08 | 261.9 | 82.63 | 21.58 | 0.57 | 200.46 |
| Lipidsa | |||||||||
| HDL-C (mg/dL) | 1466 | 51.96 | 19.04 | 1.00 | 146 | 44.49 | 17.17 | 2.64 | 131.05 |
| LDL-C (mg/dL) | 1455 | 131.96 | 39.25 | 25.20 | 346.4 | 135.31 | 37.95 | 25.00 | 307.20 |
| Triglycerides (mg/dL) | 1466 | 120.46 | 73.27 | 20.00 | 1000 | 118.84 | 79.41 | 21.00 | 995.00 |
| Total cholesterol (mg/dL) | 1466 | 207.69 | 41.68 | 49.70 | 500 | 203.58 | 38.79 | 77.00 | 438.14 |
| Steroid hormonesb | |||||||||
| Estrone (pg/mL) | 1469 | 563.16 | 1472.85 | 2.50 | 27,713 | 633.25 | 1477.97 | 2.50 | 19,708.89 |
| Testosterone (pg/mL) | 1469 | 129.78 | 171.65 | 5.00 | 5300.3 | 150.19 | 240.96 | 5.00 | 8056.94 |
| SHBG (nM) | 1470 | 77.13 | 53.51 | 6.36 | 404 | 68.23 | 51.01 | 6.00 | 404.00 |
aLipid assays were conducted as part of a previous study, so not all cases had lipid assay measurements available (4 of 1470 matched pairs missing). An additional 11 matched pairs are missing for LDL-C, because LDL-C levels are derived from fasting triglyceride levels and samples with fasting triglyceride levels over 400 mg/dl were excluded from this derivation procedure
bOne sample missing from steroid hormone assays
27HC 27-hydroxy cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol (calculated), SHBG sex hormone binding globulin, SD standard deviation