Table 3.
Poisson segmented regression models of the impact of treat-all on mean CD4 at ART initiation among PLHIV in China 1 January 2015 to 31 December 2019
| IRR (95% CI) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Level change at treat-all | P value | Level change in December 2019 |
P value | Trend before treat-all | P value | Trend after treat-all | P value | |
| Mean CD4 | 0.990 (0.956–1.026) | 0.585 | 0.973 (0.842–1.124) | 0.709 | 0.998 (0.995–1.001) | 0.196 | 0.997 (0.997–0.998) | < 0.001 |
| Gender | ||||||||
| Male | 1.001 (0.968–1.036) | 0.941 | 0.955 (0.822–1.109) | 0.548 | 0.998 (0.995–1.001) | 0.213 | 0.997 (0.996–0.998) | < 0.001 |
| Female | 0.932 (0.891–0.976) | 0.003 | 1.124 (1.092–1.156) | < 0.001 | 0.996 (0.995–0.996) | < 0.001 | 1.000 (0.999–1.001) | 0.567 |
| Age, years | ||||||||
| 0–25 | 1.015 (0.976–1.056) | 0.447 | 0.932 (0.748–1.160) | 0.526 | 1.001 (0.997–1.006) | 0.553 | 0.999 (0.999–1.000) | 0.081 |
| 26–35 | 1.002 (0.967–1.038) | 0.926 | 0.881 (0.751–1.033) | 0.118 | 1.001 (0.998–1.004) | 0.553 | 0.998 (0.997–0.999) | < 0.001 |
| 36–50 | 1.007 (0.944–1.074) | 0.841 | 1.134 (0.915–1.404) | 0.250 | 0.995 (0.991–0.999) | 0.022 | 0.998 (0.997–1.000) | 0.060 |
| > 50 | 0.971 (0.876–1.076) | 0.572 | 1.340 (0.921–1.949) | 0.126 | 0.992 (0.985–0.998) | 0.014 | 0.999 (0.998–1.000) | 0.137 |
| Route of transmission | ||||||||
| Heterosexual | 0.936 (0.852–1.027) | 0.163 | 1.137 (0.866–1.493) | 0.357 | 0.995 (0.989–1.000) | 0.058 | 0.999 (0.998–1.000) | 0.170 |
| Homosexual | 1.038 (0.994–1.084) | 0.093 | 0.941 (0.837–1.057) | 0.304 | 1.000 (0.997–1.002) | 0.743 | 0.997 (0.996–0.998) | < 0.001 |
| Others | 1.024 (0.971–1.080) | 0.380 | 0.908 (0.704–1.171) | 0.458 | 1.001 (0.996–1.006) | 0.727 | 0.998 (0.997–0.999) | 0.001 |
| Region | ||||||||
| Northern China | 1.033 (1.001–1.065) | 0.041 | 0.916 (0.808–1.040) | 0.175 | 1.002 (1.000–1.004) | 0.042 | 0.999 (0.998–1.000) | 0.113 |
| Northeastern China | 1.080 (1.003–1.164) | 0.042 | 0.805 (0.689–0.941) | 0.007 | 1.002 (0.999–1.005) | 0.126 | 0.995 (0.993–0.997) | < 0.001 |
| Southern China | 1.004 (0.939–1.074) | 0.900 | 0.700 (0.475–1.031) | 0.071 | 1.006 (0.998–1.014) | 0.118 | 0.998 (0.996–0.999) | 0.001 |
| Southwestern China | 0.926 (0.867–0.989) | 0.022 | 1.145 (0.875–1.499) | 0.322 | 0.993 (0.988–0.998) | 0.010 | 0.998 (0.997–0.999) | 0.003 |
| Eastern China | 1.109 (0.971–1.268) | 0.128 | 2.396 (1.589–3.614) | < 0.001 | 0.982 (0.975–0.990) | < 0.001 | 1.000 (0.998–1.003) | 0.768 |
IRR Incidence rate ratio, CI Confidence interval, ART Antiretroviral therapy. Treat-all: June 2016. PLHIV: People living with HIV. Region was divided into Northern China (Hohhot, Shijiazhuang, Beijing and Tianjin), Northeastern China (Dalian and Shenyang), Southern China (Guangzhou and Shenzhen), Southwestern China (Chongqing and Dehong), and Eastern China (Nanjing)