Table 4.
Threshold effect analysis examining the relationship between 25(OH)D level and lipids
| Model IIa | ||||||
|---|---|---|---|---|---|---|
| TC β (95% CI) P value |
TG β (95% CI) P value |
HDL β (95% CI) P value |
LDL β (95% CI) P value |
APO-A β (95% CI) P value |
LPa β (95% CI) P value |
|
| Model Ab | ||||||
| One line slope |
0.003 (0.003, 0.008) 0.37 |
− 0.006 (− 0.011, − 0.001) 0.03 |
0.004 (0.002, 0.006) < 0.01 |
− 0.001 (− 0.006, 0.003) 0.55 |
0.004 (0.002,0.005) < 0.01 |
1.33 (0.34,2.32) < 0.01 |
| Model Bc | ||||||
| Serum 25(OH)D turning point (K), ng/mL | 10.04 | 10.04 | 12.87 | 10.04 | 24.21 | 26 |
| < K | 0.11 (0.02, 0.19) 0.01 | 0.05 (− 0.03, 0.12) 0.26 | 0.000 (− 0.013, 0.014) 0.96 | 0.10 (0.03, 0.17) < 0.01 | 0.005 (0.002, 0.008) < 0.01 | 2.07 (0.40, 3.75) 0.02 |
| > K | 0.001 (− 0.005, 0.007) 0.82 | − 0.007 (− 0.012, − 0.001) 0.01 | 0.004 (0.002, 0.006) < 0.01 | − 0.003 (− 0.008, 0.001) 0.18 | 0.002 (− 0.000, 0.005) 0.07 | 0.45 (− 1.44, 2.34) 0.64 |
| Slope 2–Slope 1 | − 0.11 (− 0.19, − 0.02) 0.02 | − 0.05 (− 0.13, 0.03) 0.20 | 0.004 (− 0.01, 0.02) 0.60 | − 0.10 (− 0.17, − 0.03) < 0.01 | − 0.003 (− 0.007, 0.002) 0.23 | − 1.62 (− 4.59, 1.35) 0.28 |
| LRTd | 0.02 | 0.20 | 0.59 | 0.004 | 0.22 | 0.28 |
Bolded data are now presented with three decimal places, which improves the sensitivity of the data
CI confidence interval, 25(OH)D 25-hydroxy vitamin D, TC total cholesterol, TG triglyceride, HDL high-density lipoprotein, LDL low-density lipoprotein, APO-A apolipoproteina, LPa lipoproteina, BMI body mass index, β-CTX beta-C-terminal telopeptide of type I collagen, P1NP procollagen type I N-terminal propeptide, LRT logarithmic likelihood ratio test
aAdjusted for sex; age of blood collection; year of blood collection; calcium; BMI; season; main diagnosis; hypertension; diabetes; β-CTX; P1NP
bLinear analysis, P value < 0.05 indicates a linear relationship
cNonlinear analysis
dP value < 0.05 means Model B is significantly different from Model A, which indicates a nonlinear relationship