Skip to main content
. Author manuscript; available in PMC: 2023 Aug 14.
Published in final edited form as: Bioconjug Chem. 2022 Oct 4;33(10):1803–1810. doi: 10.1021/acs.bioconjchem.2c00389

Figure 1. Receptor-Mediated Transcytosis of ProSNAs Across the Blood-Brain Barrier.

Figure 1.

Cartoon representation of β-Gal ProSNAs being shuttled across an endothelial cell to the brain via the transferrin receptor. The surface of β-Gal is decorated with a shell of transferrin-specific aptamers covalently conjugated to surface lysine residues, resulting in a protein spherical nucleic acid (ProSNA). The representation was adapted from PDB ID 1PX3.