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. Author manuscript; available in PMC: 2023 Aug 14.
Published in final edited form as: Bioconjug Chem. 2022 Oct 4;33(10):1803–1810. doi: 10.1021/acs.bioconjchem.2c00389

Figure 3. Biodistribution of β-Galactosidase Following Systemic Injection in Mice.

Figure 3.

After a 1-h treatment with 6.5 mg of β-Gal/kg mouse via a tail-vein injection; mice (n = 6) were sacrificed, perfused, and their organs dissected and fixed. Using IVIS, the fluorescence from the protein’s AF647 tag was measured in the (A) brain and (B) other filtration organs. A region of interest was drawn around each organ, and the fluorescence radiant efficiency were quantified (C-D). Each dot represents an individual mouse, the bars represent the mean, and the error bars show SD. A paired t-test was performed in GraphPad Prism. *** p ≤ 0.0001, ns = not significant