Table 3.
Relevant statistically significant correlations between demographic, clinical and radiological (MRI) markers in the relapsing- and remitting-multiple sclerosis patients’ groups.
| Variable 1 | Variable 2 | Spearman’s rho | P-value |
|---|---|---|---|
| EDSS | MSFC | -0.571 | <0.0001 |
| EDSS | 9-HPT z-scores | -0.594 | <0.0001 |
| Number of relapses in the previous 24 months | Vitamin A | 0.512 | 0.0004 |
| Number of relapses in the previous 12 months | Vitamin A | 0.540 | 0.0002 |
| BMI | C3 | 0.592 | <0.0001 |
| Age | rCBV leakage* active (Gd+) lesions | 0.704 | 0.0023 |
| Disease duration | rCBF leakage* active (Gd+) lesions | 0.761 | 0.0006 |
| Number of relapses in the previous 12 months | rCBF leakage* active (Gd+) lesions | -0.734 | 0.0012 |
| PC | rCBV leakage* active (Gd+) lesions | 0.665 | 0.0049 |
| TF | MTT leakage* active (Gd+) lesions | -0.746 | 0.0009 |
| P-Selectin\CD62P | MTT leakage* active (Gd+) lesions | -0.645 | 0.007 |
| Vit K | rCBV leakage* active (Gd+) lesions | -0.827 | 0.0017 |
| Vit K | rCBF leakage* active (Gd+) lesions | -0.720 | 0.0125 |
| Vit K | MTT leakage* active (Gd+) lesions | -0.70 | 0.0182 |
| CMV IgM | MTT leakage* active (Gd+) lesions | 0.828 | 0.0001 |
| Inf B IgA | rCBV leakage* active (Gd+) lesions | 0.777 | 0.0004 |
*A leakage correction analysis was also performed, in order to correct for contrast agent extravasation.
CMV IgM, Cytomegalovirus IgM; Gd+, gadolinium-enhancing lesions; Inf B IgA, Influenza B IgA; MTT, Mean Transit Time; rCBF, relative Cerebral Blood Flow; rCBV, relative Cerebral Blood Volume; TF, Coagulation Factor III/Tissue Factor; Vit K, vitamin K.