TABLE 3.

Advantages and disadvantages of different dosimetry techniques.

Technique	Pros	Cons
Planar scintigraphy	Easily accessible and cost effective	Lack of anatomical information results in relatively low accuracy
	Suitable for routine clinical use	Organs with a high 177Lu uptake, such as the kidneys, may receive an underestimated dose
	Easy to perform and simple to understand	Inaccurate when organs overlap
SPECT	Better spatial resolution than planar scintigraphy	Specialized equipment is required
	Determine the activity distribution in three dimensions accurately	Complex and time-consuming process compared to planar scintigraphy
	An improved dose estimation method	Patient motion can affect measurements
		Inaccurate when organs overlap due to Partial Volume Effect (PVE)
Time activity curve analysis	Improves the accuracy of time activity curves for each organ	More frequent blood sampling and imaging is required
	Estimation of radiation absorbed dose is better than planar scintigraphy and SPECT	Results may vary between different institutions according to calculation methods
Monte Carlo simulation	Simulating radiation behavior in tissues with high accuracy	Computationally demanding and time-consuming
	Calculates the dosimetry accurately	Expertise and specialized software are required
		Simulation sensitivity to input parameters
Hybrid imaging	Enhances accuracy by combining anatomical and functional information	Equipment and expertise are required
	Better radiation absorbed dose estimation than planar scintigraphy or SPECT alone	Time-consuming and costly imaging
		Inaccurate when organs overlap