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. 2023 Jul 31;14:1237485. doi: 10.3389/fphar.2023.1237485

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Copyright © 2023 Castelli, Lavanco, D’Amico, Feo, Tringali, Kuchar, Cannizzaro and Brancato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The recovery effect of CBD on the impaired reinforcement-related cognitive score of pTHC-exposed adolescent rat offspring. Rats prenatally exposed to THC displayed a lower reinforcement-related cognitive integrated z-score than CTRL rats (A). CBD reversed pTHC-induced alteration in spatial and configural cognitive processing in the Can test of the adolescent offspring, by improving CR- and RE-related cognitive scores in pTHC-CBD rats tested in both spatial- (B,C) and simple visual (D,E) tasks. Each bar represents the mean of n = 10 rats; error bars indicate SEM. **p < 0.01, ****p < 0.0001. CTRL, male rat offspring prenatally exposed to Veh; pTHC, male rat offspring prenatally exposed to THC; pTHC-CBD, male rat offspring prenatally exposed to THC and exposed to CBD in adolescence; CR, correct responses; RE, reference memory errors.