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. 2023 Jul 31;14:1237485. doi: 10.3389/fphar.2023.1237485

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Copyright © 2023 Castelli, Lavanco, D’Amico, Feo, Tringali, Kuchar, Cannizzaro and Brancato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The ability of CBD to counteract the impaired aversion-related cognitive score of pTHC-exposed adolescent rat offspring. pTHC decreased the aversion-related cognitive integrated z-score (A). CBD rescued pTHC-induced impairment in the retrieval of spatial memory and reversal learning, by improving primary latency- (B) and latency to escape-related cognitive scores (C) in pTHC-CBD rats. Each bar represents the mean of n = 12 rats; error bars indicate SEM. **p < 0.01, ***p < 0.001. CTRL, male rat offspring prenatally exposed to Veh; pTHC, male rat offspring prenatally exposed to THC; pTHC-CBD, male rat offspring prenatally exposed to THC and exposed to CBD in adolescence.