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. 2023 Aug 15;133(16):e169676. doi: 10.1172/JCI169676

Figure 3. Blood gene expression profile on V1 and V7 for ViTT and ViPS recipients.

Figure 3

(A) Volcano plot of changes in blood gene expression in ViPS or ViTT recipients at V1 compared with V0. (B) Top 5 upregulated and downregulated pathways from GSEA for ViPS recipients at V1 compared with V0. (C) Top 5 upregulated and downregulated pathways from GSEA for ViTT recipients at V1 compared with V0. (D) Agreement plot of fold change of DEGs (P < 0.05) for ViPS recipients at V1 (y axis) and ViTT recipients at V1 (x axis) compared with V0. (E) Top 5 upregulated and downregulated pathways from GSEA after ViTT vaccination compared with ViPS at V1. (F) Top 5 upregulated and downregulated pathways from GSEA at V7 for both Vi vaccine groups compared with V0. (G) A module derived from WGCNA that is associated with the V7 time point. (H) Volcano plot of changes in blood gene expression for ViPS recipients at V7, compared with V0. (I) Volcano plot of changes in blood gene expression in ViTT recipients at V7 compared with V0. (J) Volcano plot of differences in gene expression for ViTT recipients compared with ViPS recipients, both at V7. (K) Modular signatures induced during different study time points; enriched modules (FDR <1 × 10–6) are displayed. Segments of the pie charts represent the proportion of upregulated (red) and downregulated (blue) genes (absolute fold change >1.25).