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. 2023 Jul 31;13:1202035. doi: 10.3389/fcimb.2023.1202035

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Copyright © 2023 Zhang, Andreu-Sánchez, Vadaq, Wang, Matzaraki, van der Heijden, Gacesa, Weersma, Zhernakova, Vandekerckhove, de Mast, Joosten, Netea, van der Ven and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prevotella copri strains with different immune functions. (A, B) Distinct associations between control-related strain and PLHIV-related strain with IL-6 and IL-10 production capacity in PLHIV, using linear regression. Association is corrected for age, sex, read counts, and sexual behavior. Blue dots represent the PLHIV with the control-related strain. Dark pink indicates PLHIV with the PLHIV-related strain. Bacterial relative abundance is CLR- and inverse-rank–transformed. (C, D) Distinct associations between relative abundance of control-related strain and PLHIV-related strain with CD4 counts (C) and CD4-recovery-abs level (D). (E) Violin plot of the P. copri epitope peptide (from glutamate 5 kinase) level between the two kinds of strains in PLHIV and HCs from the 500FG cohort.