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. 2023 Jul 31;14:1189278. doi: 10.3389/fneur.2023.1189278

Figure 2.

Figure 2

Clinical and neuropsychological features are unrelated to neuroinflammation in early AD. Panels show the relationship between the whole brain SUVR relative to the cerebellar cortex, and sex (A), age at onset (B), APOE genotype (C), cerebrovascular co-pathology (D) and MMS score (E). In addition, panels show the relationship between the temporal meta-ROI SUVR using the whole brain as a reference and the FCSRT 20-minutes total recall (F) and FCSRT 7-day total recall (G). (Panel H) represents the relationship between the SUVR of the frontal area relative to the WB and the FAB score. HAB are represented in green circles and MAB in pink triangles. Age at diagnosis was used as proxy to classify patients as early (<65 years) or late (≥65 years) onset AD (EOAD or LOAD respectively). APOE: apolipoprotein; EOAD: early onset Alzheimer’s disease; FCSRT: free and cued selective reminding test; CAA: cerebral amyloid angiopathy; FAB: frontal assessment battery; HAB: high affinity binder; LOAD: late onset Alzheimer’s disease; MAB: mixed affinity binder; MMS: mini-mental state examination; ROI: region of interest; SUVR: standard uptake value ratio.