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. 2023 Jun 22;48(10):1436–1445. doi: 10.1038/s41386-023-01622-3

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© The Author(s), under exclusive licence to American College of Neuropsychopharmacology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 2 — Changes in behavior over 13 months of food- and cocaine-reinforced responding (A–E). Mean (±SEM) number of food reinforcers (A, B) and cocaine injections (C, D) per component and total session injections (E). Each point is the mean of the last 5 sessions, each month, over 13 consecutive months. The first data points, shaded gray, are the mean ± SEM effects when saline was available in components 2 and 4. Each point represents the mean (±SEM) from 6 to 7 female cynomolgus monkeys. *p < 0.05 compared to the data from the first time point.