Table 1.

Recovery of D2/D3R ([¹¹C]Raclopride) availability following long-term cocaine self-administration in female monkeys.

Caudate nucleus
		Chronic cocaine SA		Time-off from cocaine SA			+ Chronic Rac
		100 mg/kg	1000 mg/kg	4 mo	6 mo	9 mo	30 d Tx
Subject	BL	(% BL)	(% BL)	(% BL)	(% BL)	(% BL)	(% BL)
C-7434	4.58	89	80	80	–	78	72
C-7440	3.54	–	50	–	–	83	–
C-7441	3.46	83	86	72	76	73	90
C-7453	4.30	73	63	56	97	–	–
C-7457	4.88	88	68	47	72	57	68
Mean	4.15	83.25	69.40	63.75	81.67	72.75	76.67
SEM	0.32	4.23	7.10	8.65	7.75	6.50	8.29
Putamen
C-7434	5.41	94	82	75	–	78	80
C-7440	4.19	-	50	–	–	96	–
C-7441	4.48	86	73	68	75	68	89
C-7453	5.11	80	60	60	96	–	–
C-7457	5.01	95	68	51	65	53	70
Mean	4.84	88.75	66.60	63.50	78.67	73.75	79.67
SEM	0.25	4.09	6.12	5.97	9.13	10.42	6.72
Ventral Striatum
C-7434	3.23	103	77	70	–	81	99
C-7440	3.26	-	61	–	–	98	–
C-7441	3.22	94	72	72	88	76	91
C-7453	3.27	92	64	68	94	–	–
C-7457	3.78	90	63	52	55	46	59
Mean	3.35	94.75	67.40	65.50	79.00	75.25	83.00
SEM	0.12	3.31	3.40	5.28	12.12	12.50	14.97

SA Self-administration.

The bold values show group mean data (differentiating group mean data from the individual subject data).