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. 2023 May 23;48(10):1455–1464. doi: 10.1038/s41386-023-01612-5

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© The Author(s), under exclusive licence to American College of Neuropsychopharmacology 2023, corrected publication 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 4 — A Experimental procedures. B Rats that had tone paired with foot shock delivery displayed significantly more freezing behavior in response to tone presentation than rats that were exposed to the same number of tone-shock presentations but in an unpaired manner. C Significantly greater cFos expression was observed in RMTg-projecting dmPFC neurons (CtB+) following exposure to either a series of foot shocks or a tone predictive of foot shock relative to a neutral tone or the testing context alone. D Representative images of CtB and cFos labeling in the dmPFC of a context-exposed rat and a rat exposed to foot shock. Representative CtB⁺/cFos⁻ neurons are indicated with a yellow arrowhead; Representative CtB⁻/cFos⁺ neurons are indicated with a black arrow; Representative CtB⁺/cFos⁺ neurons are indicated by a red asterisk. Inset shows representative injection site in RMTg. Scale bar = 200 μm.