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. 2022 Sep 22;39(4):1413–1431. doi: 10.1007/s10565-022-09767-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — CCL24 promoted primary cardiac fibroblast activation. A Immunofluorescence of ACTA2 in heart tissues in mice. Scale bar in panel A upper part is 50 μm; scale bar in panel A lower part is 10 μm. B CCK8 counting assay of the proliferation of cardiac primary fibroblast. The data are represented as the means ± SEM (one-way ANOVA; P = 0.0028: control group vs. CCL24 100UM group, P = 0.0006: control group vs. CCL24 250UM group, P < 0.0001: control group vs. CCL24 500UM group). C Quantitative real-time polymerase chain reaction analysis of the mRNA levels of ACTA2, COL1A1 and COL3A1 in cardiac primary fibroblast with different stimulations. The data are represented as the means ± SEM (unpaired Student’s t test; P < 0.05: control group vs. CCL24 group). D Western blot analysis of ACTA2, COL1A1, COL3A1, Tgf-β, and CCN2 protein in in cardiac primary fibroblast under different stimulation. The data are represented as the means ± SEM (unpaired Student’s t test; P < 0.05: control group vs. CCL24 group)