Table 1.
Baseline characteristics of the included RCTs in the meta-analysis
Author, year | Therapeutic schedule | Average age (years) | Male | Duration of PsA, years | PASI score (0–72) | Swollen joint count (0–66) | Tender joint count (0–68) |
---|---|---|---|---|---|---|---|
Deodhar, Atul 2018 | Guselkumab 100 mg at week 0, week 4, and every 8 weeks | 47 | 52% | 7.0 ± 7.2 | 12.0 ± 10.5 | 11.9 ± 7.6 | 20.7 ± 12.2 |
Placebo | 44 | 24% | 6.9 ± 7.2 | 9.9 ± 8.0 | 10.6 ± 7.5 | 20.1 ± 12.5 | |
Mease, Philip J. 2020 | Guselkumab 100 mg every 4 weeks | 46 | 58% | 5.5 ± 5.9 | 10.8 ± 11.7 | 12.9 ± 7.8 | 22.4 ± 13.5 |
Guselkumab 100 mg at weeks 0, 4, then every 8 weeks | 45 | 52% | 5.1 ± 5.5 | 9.7 ± 11.7 | 11.7 ± 6.8 | 19.8 ± 11.9 | |
Placebo | 46 | 48% | 5.8 ± 5.6 | 9.3 ± 9.8 | 12.3 ± 6.9 | 21.6 ± 13.1 | |
Coates, L. C. 2022 | Guselkumab 100 mg week 0, week 4, then every 8 weeks | 49 | 46% | 8.3 ± 7.8 | 11.7 ± 11.9 | 10.0 ± 7.0 | 21.0 ± 13.0 |
Placebo | 49 | 54% | 8.7 ± 7.2 | 9.2 ± 9.4 | 9.0 ± 6.0 | 18.0 ± 11.0 | |
Kristensen, L. E. 2022 | Risankizumab 150mg at weeks 0, 4 and 16 | 52 | 52% | 7.1 ± 7.0 | 10.9 ± 10.1 | 12.1 ± 7.8 | 20.8 ± 14.1 |
Placebo | 52 | 49% | 7.1 ± 7.7 | 10.0 ± 10.4 | 12.2 ± 8.0 | 20.5 ± 12.8 | |
Ostor, A. 2022 | Risankizumab 150mg at weeks 0, 4 and 16 | 53 | 45% | 8.2 ± 8.2 | 7.7 ± 6.7 | 13.0 ± 8.7 | 22.8 ± 14.9 |
Placebo | 52 | 45% | 8.2 ± 8.3 | 8.4 ± 9.9 | 13.6 ± 9.0 | 22.3 ± 13.8 | |
Philip J Mease 2021 | Tildrakizumab 200 mg every 4 weeks | 50 | 41% | 7.5 ± 8.5 | 7.6 ± 9.8 | 10.4 ± 7.4 | 16.6 ± 11.9 |
Tildrakizumab 200 mg every 12 weeks | 49 | 53% | 6.2 ± 7.2 | 6.2 ± 7.4 | 10.0 ± 8.0 | 19.5 ± 13.9 | |
Tildrakizumab 100 mg every 12 weeks | 49 | 39% | 7.0 ± 6.6 | 8.8 ± 9.5 | 11.0 ± 8.2 | 21.3 ± 14.8 | |
Tildrakizumab 20 mg every 12 weeks | 47 | 47% | 6.6 ± 6.7 | 5.5 ± 2.1 | 9.4 ± 6.4 | 19.0 ± 13.0 | |
Placebo | 48 | 44% | 6.3 ± 6.1 | 5.0 ± 6.5 | 11.8 ± 9.8 | 19.7 ± 14.7 |
RCT, randomized controlled trial; PsA, psoriatic arthritis; PASI, Psoriasis Area Severity Index