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. 2023 Jul 31;14:1183714. doi: 10.3389/fimmu.2023.1183714

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Copyright © 2023 Sailliet, Mai, Dupuy, Tilly, Fourgeux, Braud, Giral, Robert, Degauque, Danger, Poschmann and Brouard

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B cell differential expression. The two clusters of GZMB+Bregs and non-Bregs were analyzed using differential expression methods (Seurat, MAST) to identify DEGs represented in volcano plot. Each point represents a gene by its fold change difference between the two clusters and the adjusted p.value (A). Among the genes with a fold change greater than GZMB, the 15 associated to cell-surface proteins were represented as a heatmap (B). Different Bregs subsets have been characterized by several markers with variable expression in this dataset (C). Gene ontology analysis was performed on the 104 up- and 45 down-regulated DEGs. Redundent terms were then reduced using the rrvgo package (1.8.0). (D) Differential gene expression and their ontologies were also analyzed within the naive, memory and plasmablasts/plasma cells and represented in dotplots. Differences were defined as statistically significant when P<0.001 (***) and P<0.0001 (****).