Table 5:
Secondary outcomes for aberrant head circumference by different nomograms
| Head circumference (Luchenco) | Head circumference (National Fetal Growth) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| <10% | 10–90% | >90% | <10% vs. 10–90% | >90% vs. 10–90% | <10% | 10–90% | >90% | <10% vs. 10–90% | >90% vs. 10–90% | |
| One Year Exam | ||||||||||
| Bayley-III | ||||||||||
| Cognitive score | 98.7±14.3 | 99.2±13.2 | 101.8±10.9 | −2.25 (−6.27, 1.78) | 0.78 (−1.50, 3.07) | 101.3±14.3 | 99.0±12.9 | 100.9±11.8 | −0.99 (−5.21, 3.24) | 1.33 (−0.50, 3.17 ) |
| Cognitive score < 85 | 10.5 | 9.1 | 5.3 | 1.50 (0.49, 4.61) | 0.71 (0.31, 1.63) | 5.9 | 9.2 | 5.7 | 1.08 (0.23, 4.99) | 0.63 (0.33, 1.20) |
| Motor score | 93.9 ±12.6 | 97.0 ±11.4 | 96.3 ±11.2 | −4.17 (−7.91, −0.43) # | −0.80 (−2.90, 1.31) | 95.0±11.9 | 97.0±11.2 | 97.0±11.0 | −2.91 (−6.88, 1.05) | 0.25 (−1.46, 1.96) |
| Motor score < 85 | 16.2 | 9.2 | 10.5 | 2.20 (0.85, 5.70) | 1.16 (0.62, 2.18) | 15.2 | 9.0 | 8.6 | 2.17 (0.73, 6.48) | 0.89 (0.51, 1.54) |
| Language score | 96.2 ±12.7 | 94.5 ±12.6 | 95.7 ±11.9 | 0.66 (−3.42, 4.74) | 1.05 (−1.24, 3.35) | 95.3±13.4 | 94.5±12.7 | 94.2±11.7 | −1.21 (−5.58, 3.16) | 0.29 (−1.60, 2.18) |
| Language score < 85 | 18.9 | 18.4 | 16.5 | 1.06 (0.45, 2.52) | 0.91 (0.55, 1.52) | 18.2 | 18.3 | 18.9 | 1.06 (0.41, 2.74) | 0.99 (0.66, 1.48) |
| Two Year Exam | ||||||||||
| Bayley-III | ||||||||||
| Cognitive score | 90.4 ±12.8 | 90.1 ±12.3 | 91.8 ±12.5 | −1.87 (−5.48, 1.74) | 0.25 (−1.77, 2.29) | 94.7±10.8 | 90.4±12.4 | 90.7±12.2 | 0.43 (−3.42, 4.27) | 0.47 (−1.16, 2.11) |
| Cognitive score < 85 | 13.9 | 23.9 | 19.4 | 0.74 (0.27, 2.05) | 0.91 (0.54, 1.51) | 9.4 | 23.2 | 23.1 | 0.69 (0.19, 2.49) | 0.98 (0.66, 1.45) |
| Motor score | 94.1 ±12.9 | 97.3 ±11.9 | 98.1 ±12.1 | −4.54 (−8.29, −0.79) # | 0.03 (−2.08, 2.15) | 97.1±10.3 | 97.5±11.9 | 97.9±12.0 | −2.83 (−6.81, 1.15) | 0.56 (−1.14, 2.26) |
| Motor score < 85 | 11.1 | 9.9 | 10.2 | 1.38 (0.44, 4.35) | 1.21 (0.63, 2.36) | 6.3 | 9.4 | 10.0 | 0.75 (0.15, 3.71) | 1.14 (0.66, 1.97) |
| Language score | 92.4 ±16.2 | 90.5 ±15.1 | 92.4 ±14.2 | −1.04 (−5.11, 3.04) | 0.88 (−1.48, 3.23) | 96.8±19.1 | 90.4±14.9 | 91.3±13.8 | 1.63 (−2.70, 5.95) | 1.92 (0.03, 3.81) # |
| Language score < 85 | 35.1 | 33.1 | 26.6 | 1.67 (0.78, 3.57) | 0.70 (0.44, 1.13) | 30.3 | 33.8 | 29.1 | 1.61 (0.68, 3.83) | 0.65 (0.45, 0.95) # |
| Three Year Exam | ||||||||||
| DAS-II score | 91.7 ±17.1 | 90.1 ±15.3 | 91.1 ±15.6 | −0.39 (−4.54, 3.76) | −0.68 (−3.01, 1.66) | 95.1±16.5 | 89.9±15.0 | 91.0±15.7 | 1.27 (−3.08, 5.61) | 1.44 (−0.45, 3.33) |
| DAS-II score < 85 | 36.8 | 36.2 | 30.9 | 1.38 (0.65, 2.94) | 0.90 (0.57, 1.40) | 32.4 | 36.3 | 32.0 | 1.34 (0.57, 3.15) | 0.76 (0.53, 1.09) |
| Child Behavioral Checklist > 60 | 0 | 10.4 | 8.03 | * | 0.79 (0.40, 1.57) | 0 | 10.2 | 10.0 | * | 0.97 (0.58, 1.63) |
| Four Year Exam | ||||||||||
| Conners ADHD score > 60 | 18.9 | 15.9 | 17.6 | 0.91 (0.38, 2.19) | 1.36 (0.81, 2.27) | 18.8 | 16.8 | 14.0 | 0.82 (0.31, 2.14) | 0.89 (0.57, 1.39) |
| Recall of Digits Forward – low score | 18.9 | 25.4 | 21.9 | 1.09 (0.43, 2.79) | 0.96 (0.58, 1.61) | 9.4 | 25.6 | 19.8 | 0.67 (0.18, 2.53) | 0.68 (0.45, 1.04) |
| Recognition of Pictures – low score | 21.6 | 19.6 | 22.5 | 1.16 (0.50, 2.70) | 1.19 (0.73, 1.91) | 18.8 | 19.7 | 21.9 | 0.87 (0.32, 2.35) | 1.10 (0.74, 1.64) |
| Five Year Exam | ||||||||||
| Child Behavioral Checklist > 60 | 7.9 | 10.9 | 7.1 | 0.72 (0.21, 2.46) | 0.62 (0.30, 1.25) | 5.9 | 11.8 | 8.6 | 0.56 (0.13, 2.50) | 0.62 (0.36, 1.05) |
For binary outcomes, the adjusted OR (95% CI) from logistic models is presented. For continuous outcomes, the regression coefficient (β, 95% CI) from linear regression models is presented and reflects the adjusted difference in score (i.e. score for aberrant birthweight – score for AGA).
None of the comparisons were statistically significant except for these ones marked with (#) which had a p<0.05
Not computed due to 0 cases SGA.
Regression models adjusted for gestational age at delivery, race-ethnicity, maternal age, parity, education, type of insurance, smoking status, baseline thyroid status (subclinical hypothyroidism or hypothyroxinemia), treatment group, and child sex.