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. Author manuscript; available in PMC: 2023 Sep 28.
Published in final edited form as: Biol Psychiatry. 2023 Feb 15;94(6):466–478. doi: 10.1016/j.biopsych.2023.02.009

Figure 2. Adult hippocampus rSNPs and complex context-dependent, polygenic architecture of the RSRC1 locus.

Figure 2.

Boxplots show single-barcode (BC) expression levels adjusted for random effects across analyzed replicates. Center bars: median; boxes: 25–75% quantile; whiskers: observations spanning box edges to ± 1.5*interquantile range (IQR); single points: observed values outside whisker range. Notched regions span ± 1.58 * IQR / sqrt (n measurements), approximating the 95% confidence interval for comparing median BC expression (84). rSNPs corresponding to RERE locus (38) tag variants (A) rs301806 and (B) rs301807 are shown. (C, D) Sex-interacting SNPs from the RSRC1 locus (40) included (C) rs67446837 and (D) rs1048243. (E) rSNPs identified in the RSRC1 locus and their regulatory target genes in human tissues ascertained by Hi-C. A plot of rSNP effects, colored by most significant condition, is embedded with its x-axis in human genomic (hg19) coordinates; chromatin contacts between the SNPs and distal gene promoters are illustrated below (60–64). Curve heights correspond to −log10pemp for the plotted rSNP. iPSC: Induced pluripotent stem cell; DG: dentate gyrus; Ctx: cortex. *: pemp-derived FDR < 0.25; **: <0.2; ‡ < 0.15; ‡‡ < 0.1; & < 0.05.