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. Author manuscript; available in PMC: 2023 Sep 28.
Published in final edited form as: Biol Psychiatry. 2023 Feb 15;94(6):466–478. doi: 10.1016/j.biopsych.2023.02.009

Figure 3. Shared regulatory architecture of rSNPs by sex, cell type, and sex-interacting SNP type.

Figure 3.

(A) TFs with binding motif disruptions by ≥ 4 nominally significant (empirical p < 0.05) rSNPs or sex-interacting rSNPs, enriched relative to nonfunctional SNPs. Number of rSNPs associated to a given binding site are shown. (B) Terms from Enrichr (85) analysis, identifying shared upstream regulators (TFs controlling expression of several of the TFs in panel A), brain regions enriched for expression of the rSNP-enriched TFs, protein interactors enriched among rSNP-enriched TFs, and MSigDB pathway term enrichment for rSNP-enriched TF sets. Bolded enrichments are discussed in the text.