Table 3.
Selected variants in C10orf90 associated with the risk of colorectal cancer.
| SNP | Model | Genotype | Control | Case | Without adjusted | With adjusted | ||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | |||||
| rs12412320 | Genotype | G/G | 377 (56.1%) | 427 (64.1%) | 1 | |||
| G/T | 255 (38.0%) | 205 (30.8%) | 0.71 (0.56, 0.89) | 0.004* | 0.70 (0.56, 0.89) | 0.003* | ||
| T/T | 40 (6.0%) | 34 (5.1%) | 0.75 (0.46, 1.21) | 0.239 | 0.74 (0.46, 1.19) | 0.211 | ||
| Dominant | G/G | 377 (56.1%) | 427 (64.1%) | 1 | ||||
| G/T-T/T | 295 (43.9%) | 239 (35.9%) | 0.72 (0.57, 0.89) | 0.003* | 0.71 (0.57, 0.88) | 0.002* | ||
| Recessive | G/G-G/T | 632 (94.0%) | 632 (94.9%) | 1 | ||||
| T/T | 40 (6.0%) | 34 (5.1%) | 0.85 (0.53, 1.36) | 0.498 | 0.84 (0.52, 1.34) | 0.463 | ||
| Additive | --- | --- | --- | 0.78 (0.65, 0.93) | 0.007* | 0.77 (0.64, 0.93) | 0.005* | |
| rs11245007 | Genotype | C/C | 207 (30.9%) | 192 (28.8%) | 1 | |||
| C/T | 322 (48.0%) | 308 (46.2%) | 1.03 (0.80, 1.33) | 0.810 | 1.04 (0.81, 1.34) | 0.747 | ||
| T/T | 142 (21.2%) | 166 (24.9%) | 1.26 (0.94, 1.70) | 0.128 | 1.27 (0.94, 1.72) | 0.113 | ||
| Dominant | C/C | 207 (30.9%) | 192 (28.8%) | 1 | ||||
| C/T-T/T | 464 (69.2%) | 474 (71.2%) | 1.10 (0.87, 1.39) | 0.420 | 1.13 (0.88, 1.41) | 0.375 | ||
| Recessive | C/C-C/T | 529 (78.8%) | 500 (75.1%) | 1 | ||||
| T/T | 142 (21.2%) | 166 (24.9%) | 1.24 (0.96, 1.60) | 0.103 | 1.24 (0.96, 1.61) | 0.098 | ||
| Additive | --- | --- | --- | 1.12 (0.96, 1.30) | 0.144 | 1.12 (0.97, 1.30) | 0.127 | |
| rs11245008 | Genotype | C/C | 524 (77.9%) | 497 (74.6%) | 1 | |||
| C/T | 135 (20.1%) | 155 (23.3%) | 1.21 (0.93, 1.57) | 0.152 | 1.21 (0.93, 1.58) | 0.148 | ||
| T/T | 14 (2.1%) | 14 (2.1%) | 1.05 (0.50, 2.23) | 0.890 | 1.03 (0.49, 2.20) | 0.931 | ||
| Dominant | C/C | 524 (77.9%) | 497 (74.6%) | 1 | ||||
| C/T-T/T | 149 (22.1%) | 169 (25.4%) | 1.20 (0.93, 1.54) | 0.164 | 1.20 (0.93, 1.54) | 0.164 | ||
| Recessive | C/C-C/T | 659 (97.9%) | 652 (97.9%) | 1 | ||||
| T/T | 14 (2.1%) | 14 (2.1%) | 1.01 (0.48, 2.14) | 0.978 | 0.99 (0.47, 2.11) | 0.987 | ||
| Additive | --- | --- | --- | 1.15 (0.92, 1.44) | 0.218 | 1.15 (0.92, 1.44) | 0.223 | |
SNP, Single nucleotide polymorphis; OR, Odds ratio; 95% CI, 95% confidence interval.
p values were calculated by logistic regression analysis without and with adjusted by sex, age, smoking, and drinking
*p < 0.05 was considered statistical significance.
Bold p means that the data is statistically significant after Bonferroni correction (p < 0.05/3).