FIG. 1.

Body weight changes during the late stage of CDV infection. The effect of CDV infection on body weight in three different experiments with Swiss mice (experiments [Exp.] (A and B) and C3H mice (experiment C) are shown. The mice were weighed weekly over the period from 5 to 8 months after viral inoculation in experiment A (3 months of surveillance). In experiments B and C, the mice were examined over a period from 8 to 13 and 5 to 6 months after inoculation, respectively (corresponding to 5 and 2 months of surveillance, respectively, in B and C). The data are the mean (cumulative data) + standard error of the mean for each experiment. The number of mice in each experiment was as follows: (A) sham inoculated, n = 6; lean, n = 4; obese, n = 1; (B) sham inoculated, n = 5; lean, n = 2; obese, n = 1; (C) sham inoculated, n = 5; lean, n = 5; obese, n = 2. A significant increase in body weight was seen for obese mice versus either lean mice (P < 0.0002 [A], 0.0001 [B], and 0.005 [C]) or sham-inoculated mice (P < 0.001 [A], 0.0001 [B], and 0.005 [C]) (Student’s t test).