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. 2023 Aug 10;37:101758. doi: 10.1016/j.tranon.2023.101758

Fig. 6.

Fig 6

c-Myc-SRSF10 axis promotes proliferation of breast cancer cells. (A) Colony formation assay performed in WT BBS, BBS Mut, and BBS Mut MCF7 cells subjected to 5 mM l-lactate treatment for 10 days. (B) Cell migration analysed via wound healing assay in WT BBS, BBS Mut, and BBS Mut MCF7 cells subjected to 5 mM l-lactate treatment for 48 h. (C) Spheroid formation assay performed in WT BBS, BBS Mut, and BBS Mut MCF7 cells subjected to 5 mM l-lactate treatment for 6 days. (D) Kaplan–Meier curve showing significant association (p-value 0.036) of Recurrence Free survival with c-Myc expression in Breast Cancer TCGA dataset (GSE9195). (E) Graphical illustration of the H3K18la-driven c-Myc-SRSF10 axis.