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. 2023 Jun 28;29(16):3026–3036. doi: 10.1158/1078-0432.CCR-23-0416

Figure 3.

Figure 3. Baseline tumor characteristics in clinical responders and nonresponders. A, TMB and (B) predicted neoantigen in all patients with available baseline biopsy. C, Baseline multiplex immunofluorescence staining of T cells (CD4+ and CD8+), regulatory CD4 T cells (CD4+/FoxP3+), granzyme B+, hTERT+, Ki67+, and melanoma cells (Sox10+/S100+). Two samples with no Sox10/S100 stained cells were excluded from the analysis of co-staining melanoma cells and hTERT and Ki67. D, Among all available biopsies (both baseline and week 14), there was a significant correlation between signal intensity of Ki67 and TERT within melanoma cells (simple linear regression, R2 = 0.267; P = value 0.002). E, Baseline levels of the 18-gene IFNγ gene signature expression according to iRECIST category. Heat map shows the calculated z-score, representing the relative expression levels across patient samples. Unless otherwise described, all reported P values represent results from the unpaired nonparametric test (Mann–Whitney). ND, not detected. R, clinical responder. NR, clinical nonresponders.

Baseline tumor characteristics in clinical responders and nonresponders. A, TMB and (B) predicted neoantigen in all patients with available baseline biopsy. C, Baseline multiplex immunofluorescence staining of T cells (CD4+ and CD8+), regulatory CD4 T cells (CD4+/FoxP3+), granzyme B+, hTERT+, Ki67+, and melanoma cells (Sox10+/S100+). Two samples with no Sox10/S100 stained cells were excluded from the analysis of co-staining melanoma cells and hTERT and Ki67. D, Among all available biopsies (both baseline and week 14), there was a significant correlation between signal intensity of Ki67 and TERT within melanoma cells (simple linear regression, R2 = 0.267; P = value 0.002). E, Baseline levels of the 18-gene IFNγ gene signature expression according to iRECIST category. Heat map shows the calculated z-score, representing the relative expression levels across patient samples. Unless otherwise described, all reported P values represent results from the unpaired nonparametric test (Mann–Whitney). ND, not detected. R, clinical responder. NR, clinical nonresponders.