Evaluation of association between volume and PRO changes. Response associations for Patients 33 and 103 for insomnia, dizziness, fatigue, and the combination of the three were analyzed using assessments taken within 1 week of each volume measurement. For Patient 33, changes in insomnia matched well with changes in volume. Changes in dizziness did not align with changes in volume, whereas fatigue and the aggregate had partial alignment. For Patient 103, initial changes in insomnia matched well with volume changes. The patient experienced a decline in all four PROs at the last assessment, despite an increase in volume.