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. 2023 Jan 3;11(1):449–463. doi: 10.1016/j.gendis.2022.12.003

Figure 1.

Fig. 1

CD36 expression level was increased in AKI. (A) Cisplatin-induced AKI with elevated Scr and BUN levels (n = 8; ∗P < 0.05 vs. control group). (B) Transcriptome sequencing results indicated that CD36 gene was up-regulated. (C) CD36 mRNA level in mouse kidney (n = 3) quantified via qPCR. (D) Western blotting was used to detect CD36 expression in mouse kidney tissues (n = 3). (E) Representative images of immunohistochemical staining and quantitative statistics of relative CD36 area in mice (n = 3). (F) Quantitative statistical analysis of relative CD36 area from (E). (G) CD36 mRNA level in TCMK-1 cells (n = 3) quantified via qPCR. (H) Western blotting was used to detect CD36 expression in TCMK-1 cells (n = 3). All data are expressed as means ± standard deviation. ∗P < 0.05 and ∗∗P < 0.01 vs. control group. (I) Representative CD36 images of immunohistochemical and pathological sections (HE and PAS) in kidney tissue samples from clinical patients. Scale bars = 100 μm. (J) Renal function levels, including Scr, BUN, and GFR in clinical samples. (K) Representative immunohistochemical staining images of relative CD36 area in human AKI sample. (L) Quantitative statistical analysis of relative CD36 area from (K). (M–O) Pearson correlation analysis between CD36 expression and renal function.