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. 2023 Mar 27;11(1):294–305. doi: 10.1016/j.gendis.2023.02.016

Figure 3.

Fig. 3

Ligands in the extracellular matrix interact with the N-terminal fragment to activate GPR126 signaling. The activation enhances Gs-mediated signaling via the accumulation of cAMP to drive SC terminal differentiation and myelination.