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. 2023 Mar 25;11(1):268–282. doi: 10.1016/j.gendis.2023.02.027

Table 3.

Nanotechnology-based delivery systems for CRISPR/Cas9.

Delivery system Cargo options Advantages Disadvantages
Polymer nanoparticles RNP plasmid DNA; RNP complex; Cas9 mRNA; sgRNA; donor DNA High biocompatibility; low immunogenicity; ability to reduce off-target effects; mass production; low cost Toxicity; limited delivery efficiency
Golden nanoparticles RNP plasmid DNA; RNP complex; Cas9 mRNA; sgRNA; donor DNA High biocompatibility; low immunogenicity; ability to reduce off-target effects; mass production; low cost Limited delivery efficiency
Lipid nanoparticles RNP plasmid DNA; RNP complex; Cas9 mRNA; sgRNA; donor DNA High biocompatibility; low immunogenicity; ability to reduce off-target effects; mass production; low cost Degradation in vivo