Skip to main content
. 2023 Jul 10;42(16):e112446. doi: 10.15252/embj.2022112446

Figure EV5. Genetic inhibition of ntl‐2 shortens the lifespan of long‐lived insulin/IGF‐1 pathway mutants and differentially impacts longevity of animals with compromised mitochondrial function.

Figure EV5

  1. Knockdown of ntl‐2 shortens the lifespan of daf‐2(RNAi) long‐lived animals.
  2. Knockdown of ntl‐2 shortens the lifespan of age‐1(hx546) mutants.
  3. Knockdown of ntl‐2 shortens the lifespan of akt‐1(ok525) mutants.
  4. Knockdown of atp‐3 rescues the short lifespan of NTL‐2‐depleted animals.
  5. mev‐1(kn1) mutation is beneficial for the lifespan of NTL‐2‐depleted animals.
  6. Knockdown of isp‐1 rescues the short lifespan of NTL‐2‐depleted animals.
  7. nuo‐6(qm200) mutation is beneficial for the lifespan of NTL‐2‐depleted animals.

Data information: Lifespan assays were performed at 20°C; detailed data are given in Table EV4.