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. 2023 Jul 10;42(16):e112446. doi: 10.15252/embj.2022112446

Figure 6. Storage and degradation body components oppositely influence stress resistance and longevity.

Figure 6

  1. Per cent survival of wild‐type, DCAP‐2‐ and NTL‐2‐depleted animals subjected to heat stress for 5 h at 37°C and then counted every 24 h (n = 4 independent experiments with at least 294 animals/experiment).
  2. Per cent survival of wild‐type, DCAP‐2‐ and NTL‐2‐depleted animals following paraquat (8 mM) administration and counted every 24 h (n = 4 independent experiments with at least 144 animals/experiment).
  3. Per cent survival of wild‐type, DCAP‐2‐ and NTL‐2‐depleted animals counted every 24 h post‐CCCP (15 μM) treatment (n = 4 independent experiments with at least 116 animals/experiment).
  4. Per cent survival of wild‐type and daf‐2(e1370)‐mutant animals subjected to ntl‐2 knockdown 24 h post‐paraquat (10 mM) administration (n = 4 independent experiments with at least 150 animals/experiment; ****P < 0.0001, two‐way analysis of variance (ANOVA)).
  5. Knockdown of ntl‐2 shortens the lifespan of wild‐type animals, while NTL‐2 overexpression extends lifespan.

Data information: Error bars denote SEM. Lifespan assays were performed at 20°C; detailed data are given in Tables [Link], [Link].