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. 2023 Jul 10;42(16):e112446. doi: 10.15252/embj.2022112446

Figure 7. The detrimental effects of ntl‐2 genetic inhibition on lifespan are ameliorated upon local translation perturbation.

Figure 7

  1. Knockdown of akap‐1 extends the lifespan of wild‐type animals, while it does not further extend the lifespan of NTL‐2‐overexpressing animals.
  2. Knockdown of akap‐1 reverses the lifespan shortening of ntl‐2‐mutant worms.
  3. Knockdown of akap‐1 ameliorates the lifespan shortening caused by ntl‐2 genetic inhibition (double RNAi administered as 1:1 mixture).

Data information: Lifespan assays were performed at 20°C; detailed lifespan data are given in Table EV4.