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. 2023 Jul 10;42(16):e110757. doi: 10.15252/embj.2022110757

Figure 3. GC response identified in cervical cancer.

Figure 3

  1. UMAP plot showing the subtypes of 3,107 B cells. Cluster annotations are denoted and coloured corresponding to cell types in the figure.
  2. Heatmap showing the characterization of different B‐cell populations with B‐cell‐related pathways.
  3. Dot plot showing the selected signaling pathways (rows) with significant enrichment of GO terms for B‐cell and plasma clusters.
  4. 2D graph of B cells trajectories. The cell density distribution, by the pseudo‐time, is shown at the top of the figure and colored corresponding to cell types.
  5. Heatmap showing immune‐associated genes in the differentiation process.
  6. Stacked bar plot showing immunoglobulin (Ig) abundance of each B cell sub‐cluster.
  7. A forest plot showing the association of different B‐cell signatures with survival across the TCGA SCC cohort. Squares and lines indicate hazard ratios (HRs) and 95% confidence intervals (CIs), respectively. HRs were calculated using univariable Cox regression; P‐values were calculated using log‐rank test.
  8. Violin plots showing the association of different B‐cell signatures with the response (R, N = 15) and no response (NR, N = 42) to Pembrolizumab in the Kim cohort. P‐values calculated using the student's t‐test.
  9. Representative mIHC of plasma cells in CC tumor area. plasma cells: CD38+Pan‐CK−, scale bar = 100 μm.
  10. Expression of the genes that comprise the plasma cell and ADCC signatures in TCGA cohort.

Data information: Violin plots show the median and upper/lower quartiles.