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. 2023 Jul 10;42(16):e110757. doi: 10.15252/embj.2022110757

Figure EV3. Clinical performance of B cell populations and BCR repertoire profiling using TRUST predicted data.

Figure EV3

  1. Heatmap showing the expression of marker genes in each subtype of B cells.
  2. Representative example of tumor versus normal clones from TRUST predicted BCR data, showing both chains, with filled points representing clones suggesting a significant change in frequency.
  3. Boxplots showing each cell type BCR Clonality level for matched tumor and normal samples by using TRUST predicted BCR data. Student's t‐test, P < 0.05 was considered statistical significance.
  4. Violin plots showing the association of different B‐cell signatures with the response (R, N = 4) and no response (NR, N = 11) to Ipilimumab in the Nathanson 15 cohort. P‐values calculated using the student's t‐test.
  5. Scatter plot showing the correlation between the bulk sample with CTL score and the single‐cell B cell clusters.
  6. Heatmap showing the expression level of immunoregulator genes in B‐cell populations.

Data information: Boxplots show the median and upper/lower quartiles (Related to Fig 3).