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. 2023 Jul 10;42(16):e110757. doi: 10.15252/embj.2022110757

Figure 4. Localization and interactions of B cells and TLS in CC.

Figure 4

  • A, B
    B cell subsets localization in CC tissues are exhibited by mIHC via differential markers as follow: total B cell: CD20+, GCB: CD20+BCL6‐, PC: CD20‐CD38+; with scale =500 μm for (A), scale = 200 μm for (B).
  • C
    Quantification of B‐cell density in Pan‐CK+ tumor area, adjacent stroma and TLS. *P < 0.05, two‐way ANOVA following Tukey post‐hoc test.
  • D
    Bubble plots showing the interactions between Tfh (CD4_CXCL13) and B‐cell populations using CellPhoneDB.
  • E
    Representative mIHC of CC tumor with CD4+PD‐1+CXCL13+ Tfh cells located in TLS (yellow arrows). scale bars = 100 μm for left panel, scale bars = 20 μm for right panel.