Table 3.
Abundances of bacteria significantly differ between WT and Abcb1a KO mice (light gray) and mice fed either a casein-based or a red meat-based diet (Dark gray).
| Knockout | Wild-type | Meat | Plant | Knock-out/Wild-type % | Meat/Plant % | GLM ANOVA | Holm-Sidak | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Value of p | Adjusted value of p | |||||||||||||
| N = 22 | N = 24 | N = 20 | N = 26 | Geno-type | Diet | Geno-type | Diet | |||||||||||
| Blautia | 4.9 | ± | 3.0 | 0.0 | ± | 0.0 | 1.6 | ± | 2.0 | 2.9 | ± | 3.8 | NA | 53.7 | 0.000 | 0.000 | 0.000 | 0.000 |
| Cellulosilyticum | 2.0 | ± | 3.1 | 0.0 | ± | 0.0 | 0.0 | ± | 0.0 | 1.7 | ± | 3.0 | NA | 0.0 | 0.000 | 0.000 | 0.000 | 0.000 |
| Escherichia/Shigella | 8.7 | ± | 1.7 | 0.1 | ± | 0.4 | 5.3 | ± | 4.4 | 3.4 | ± | 4.4 | 5793.2 | 154.2 | 0.000 | 0.520 | 0.000 | 1.000 |
| Parasutterella | 10.8 | ± | 0.7 | 0.3 | ± | 0.6 | 6.8 | ± | 5.4 | 4.2 | ± | 5.1 | 3339.3 | 163.7 | 0.000 | 0.013 | 0.000 | 0.351 |
| Coprobacillus | 3.5 | ± | 2.1 | 0.4 | ± | 1.0 | 1.5 | ± | 2.1 | 2.1 | ± | 2.3 | 879.9 | 73.4 | 0.000 | 0.012 | 0.000 | 0.337 |
| unclass._Enterobacteriaceae | 8.7 | ± | 1.6 | 1.7 | ± | 1.8 | 5.9 | ± | 3.8 | 4.4 | ± | 4.0 | 514.4 | 133.3 | 0.000 | 0.778 | 0.000 | 1.000 |
| Flavonifractor | 5.9 | ± | 1.4 | 2.7 | ± | 1.1 | 4.2 | ± | 2.2 | 4.3 | ± | 2.0 | 219.7 | 99.2 | 0.000 | 0.051 | 0.000 | 0.744 |
| unclass._Haloplasmataceae | 3.3 | ± | 2.2 | 1.5 | ± | 1.6 | 2.7 | ± | 2.2 | 2.1 | ± | 2.0 | 216.3 | 125.5 | 0.006 | 0.882 | 0.075 | 1.000 |
| unclass._Erysipelotrichacea | 7.7 | ± | 1.4 | 4.3 | ± | 1.3 | 6.8 | ± | 2.5 | 5.2 | ± | 1.5 | 176.6 | 129.9 | 0.000 | 0.056 | 0.000 | 0.763 |
| Parabacteroides | 7.6 | ± | 1.4 | 5.3 | ± | 0.9 | 6.6 | ± | 1.4 | 6.3 | ± | 1.8 | 143.0 | 105.5 | 0.000 | 0.967 | 0.000 | 1.000 |
| Anaerotruncus | 3.8 | ± | 1.5 | 3.0 | ± | 1.3 | 3.1 | ± | 1.6 | 3.5 | ± | 1.3 | 125.6 | 89.7 | 0.034 | 0.383 | 0.268 | 1.000 |
| unclass._Desulfovibrionacea | 4.4 | ± | 1.9 | 3.6 | ± | 3.7 | 3.9 | ± | 2.8 | 4.0 | ± | 3.1 | 122.7 | 96.8 | 0.947 | 0.703 | 0.989 | 1.000 |
| Barnesiella | 1.9 | ± | 1.7 | 1.6 | ± | 1.4 | 2.5 | ± | 1.4 | 1.1 | ± | 1.4 | 121.0 | 237.9 | 0.841 | 0.001 | 0.989 | 0.034 |
| Bacteroides | 10.9 | ± | 0.7 | 9.5 | ± | 1.0 | 10.2 | ± | 0.8 | 10.1 | ± | 1.3 | 115.1 | 101.5 | 0.000 | 0.119 | 0.000 | 0.946 |
| unclass._Clostridiales | 9.3 | ± | 0.6 | 8.4 | ± | 0.8 | 9.2 | ± | 0.8 | 8.6 | ± | 0.8 | 111.6 | 106.5 | 0.000 | 0.043 | 0.000 | 0.720 |
| Lactobacillus | 6.6 | ± | 1.7 | 6.7 | ± | 2.2 | 7.7 | ± | 1.6 | 5.8 | ± | 1.7 | 98.2 | 133.6 | 0.270 | 0.000 | 0.890 | 0.000 |
| unclass._Anaeroplasmataceae | 2.8 | ± | 3.5 | 2.9 | ± | 3.6 | 3.3 | ± | 3.7 | 2.5 | ± | 3.4 | 96.6 | 130.9 | 0.729 | 0.466 | 0.989 | 1.000 |
| unclass._Marinilabiliaceae | 6.6 | ± | 1.9 | 7.7 | ± | 1.3 | 7.3 | ± | 1.4 | 7.1 | ± | 1.9 | 86.3 | 102.4 | 0.009 | 0.388 | 0.103 | 1.000 |
| Mucispirillum | 6.6 | ± | 2.9 | 7.6 | ± | 1.1 | 6.5 | ± | 3.0 | 7.6 | ± | 1.2 | 86.0 | 86.3 | 0.673 | 0.631 | 0.989 | 1.000 |
| unclass._Ruminococcaceae | 8.4 | ± | 1.2 | 10.1 | ± | 0.4 | 8.8 | ± | 1.5 | 9.6 | ± | 0.9 | 83.7 | 92.0 | 0.000 | 0.102 | 0.000 | 0.924 |
| unclass._Porphyromonadaceae | 9.0 | ± | 1.9 | 11.2 | ± | 0.5 | 9.9 | ± | 1.8 | 10.3 | ± | 1.7 | 80.3 | 96.4 | 0.000 | 0.996 | 0.000 | 1.000 |
| unclass._Lachnospiraceae | 8.6 | ± | 1.0 | 11.2 | ± | 0.5 | 9.4 | ± | 1.7 | 10.4 | ± | 1.3 | 76.8 | 89.7 | 0.000 | 0.028 | 0.000 | 0.585 |
| unclass._Cyclobacteriaceae | 1.7 | ± | 1.4 | 2.2 | ± | 1.6 | 1.8 | ± | 1.4 | 2.1 | ± | 1.6 | 76.7 | 86.7 | 0.313 | 0.788 | 0.895 | 1.000 |
| Oscillibacter | 5.7 | ± | 2.0 | 7.6 | ± | 1.0 | 6.1 | ± | 2.1 | 7.1 | ± | 1.5 | 74.5 | 86.4 | 0.000 | 0.307 | 0.000 | 0.999 |
| Alistipes | 6.4 | ± | 2.7 | 9.4 | ± | 1.2 | 7.6 | ± | 3.1 | 8.3 | ± | 2.0 | 68.5 | 91.6 | 0.000 | 0.519 | 0.000 | 1.000 |
| Anaeroplasma | 1.7 | ± | 3.2 | 2.6 | ± | 3.5 | 2.1 | ± | 3.6 | 2.2 | ± | 3.2 | 64.2 | 94.6 | 0.338 | 0.885 | 0.895 | 1.000 |
| unclass._Coriobacteriaceae | 1.9 | ± | 1.5 | 3.0 | ± | 1.2 | 2.5 | ± | 1.4 | 2.3 | ± | 1.5 | 62.8 | 108.7 | 0.010 | 0.311 | 0.105 | 0.999 |
| unclass._Flammeovirgaceae | 1.4 | ± | 1.2 | 2.7 | ± | 1.2 | 1.9 | ± | 1.4 | 2.2 | ± | 1.4 | 49.6 | 88.5 | 0.000 | 0.820 | 0.000 | 1.000 |
| unclass._Eubacteriaceae | 1.2 | ± | 1.8 | 2.5 | ± | 2.0 | 1.7 | ± | 2.0 | 2.0 | ± | 2.0 | 49.0 | 85.8 | 0.015 | 0.990 | 0.140 | 1.000 |
| unclass._Prevotellaceae | 0.9 | ± | 1.2 | 2.3 | ± | 2.3 | 1.6 | ± | 1.8 | 1.6 | ± | 2.1 | 41.3 | 98.1 | 0.056 | 0.711 | 0.369 | 1.000 |
| unclass._Syntrophomonadacea | 1.2 | ± | 1.8 | 3.4 | ± | 1.7 | 1.9 | ± | 1.8 | 2.7 | ± | 2.2 | 36.0 | 71.2 | 0.000 | 0.605 | 0.000 | 1.000 |
| Enterorhabdus | 0.5 | ± | 0.8 | 1.6 | ± | 1.2 | 0.7 | ± | 0.9 | 1.4 | ± | 1.2 | 33.0 | 54.7 | 0.002 | 0.230 | 0.028 | 0.997 |
| unclass._Carnobacteriaceae | 0.5 | ± | 1.0 | 2.1 | ± | 1.4 | 1.6 | ± | 1.7 | 1.1 | ± | 1.2 | 22.5 | 141.5 | 0.000 | 0.045 | 0.000 | 0.725 |
| unclass._Halothiobacillacea | 0.8 | ± | 1.1 | 3.7 | ± | 1.6 | 2.2 | ± | 1.9 | 2.4 | ± | 2.1 | 20.7 | 91.9 | 0.000 | 0.280 | 0.000 | 0.999 |
| Butyrivibrio | 0.7 | ± | 1.3 | 3.5 | ± | 2.0 | 1.9 | ± | 2.1 | 2.3 | ± | 2.4 | 18.6 | 81.6 | 0.000 | 0.570 | 0.000 | 1.000 |
| unclass._Peptostreptococcac | 0.3 | ± | 1.4 | 3.1 | ± | 2.2 | 2.2 | ± | 2.9 | 1.5 | ± | 1.8 | 9.9 | 148.4 | 0.000 | 0.046 | 0.000 | 0.725 |
| unclass._Heliobacteriaceae | 0.2 | ± | 1.0 | 3.1 | ± | 1.4 | 1.8 | ± | 2.1 | 1.6 | ± | 1.7 | 6.9 | 116.6 | 0.000 | 0.021 | 0.000 | 0.493 |
| unclass._Defluviitaleaceae | 0.1 | ± | 0.6 | 2.6 | ± | 1.6 | 1.6 | ± | 2.1 | 1.2 | ± | 1.4 | 5.0 | 130.8 | 0.000 | 0.029 | 0.000 | 0.586 |
White row show bacteria only significantly different before Holm-Sidak correction.