Table 2. Biological Activity and Physicochemical Properties of Truncated Analogues^a.

ID	R	7	L.inf pEC50	PMM pCC50	SI	aq. sol.b	HLM clintc	RH clintd	LLEe
7b	NH2	OMe	4.5	4.2	2	290	120	7.1	4.1
11a	H	H	4.3	4.2	1	828	130	140	2.6
11b	H	OMe	4.6	4.2	3	723	>300	53	2.4
12	Cl	OMe	4.8	4.5	2	562	>300	17	2.2

^ant, not tested.

^bThermodynamic aqueous solubility μM.

^cμL/min/mg protein.

^dμL/min/10⁶ cells.

^eLLE = pEC₅₀ – LogD_7.4.