Table 7. Hybrid Analogues That Combine the Most Promising Modifications for L. infantum Activity and Physicochemical Property Modulation.

ID	R1	R2	R3	L.inf pEC50	PMM pCC50	SI	aq. sol.a	HLM clintb	RH clintc	logD7.4	LLEd
3ah	OMe	H	A	5.9	5.1	6	0.4	240	>300	5.2	0.7
3ai	OMe	H	B	5.6	4.8	6	1	44	76	4.8	0.8
4m	OMe	Me	B	6.1	5.4	5	27	260	>300	3.7	2.4
4k	H	Me	A	6.3	4.5	63	26	210	>300	3.4	2.9
4l	H	Me	B	6.3	5.1	16	10	93	>300	3.7	2.6
4a	H	Me	C	6.0	5.4	4	120	110	>300	3.7	2.3
4n	OMe	Me	C	6.1	5.1	10	17	250	>300	2.9	3.2

^aThermodynamic aqueous solubility μM.

^bμL/min/mg protein.

^cμL/min/10⁶ cells.

^dLLE = pEC₅₀ – LogD_7.4.