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. 2023 Aug 15;22:137. doi: 10.1186/s12943-023-01841-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Regulation of m6A modification. The writers and erasers of m6A are responsible for regulating the methylation level of related RNA. Then, various m6A readers can recognize and combine with m6A modified RNA to regulate gene expression. METTL3, Methyltransferase-like 3; METTL14, Methyltransferase-like 14; WTAP, Wilms tumor 1-associated protein; RBM15, RNA binding motif protein 15; VIRMA, Vir-like m6A methyltransferase associated; ZC3H13, zinc finger CCCH-type containing 13; METTL16, Methyltransferase-like 16; METTL5, Methyltransferase-like 5; ZCCHC4, zinc finger CCHC-type containing 4; FTO, Fat mass and obesity-associated protein; ALKBH3, ALKB homologue 3; ALKBH5, ALKB homologue 5; YTHDF1, YTH N6-Methyladenosine RNA Binding Protein 1; YTHDF2, YTH N6-Methyladenosine RNA Binding Protein 2; YTHDF3, YTH N6-Methyladenosine RNA Binding Protein 3; YTHDC1, YTH Domain Containing 1; YTHDC2, YTH Domain Containing 2; HNRNPA2B1, Heterogeneous nuclear ribonucleoprotein A2B1; HNRNPAC/G, Heterogeneous nuclear ribonucleoprotein C/G; HNRNPR, Heterogeneous nuclear ribonucleoprotein R; IGF2BP1-3, Insulin Like Growth Factor Binding Protein 1–3; NKAP, NF-κB activating protein; eIF3, Eukaryotic translation initiation factor 3