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. 2023 Aug 14;13:150. doi: 10.1186/s13578-023-01101-8

Table 2.

Examples of advances in LLPS-based resistance against lung cancer

Targets Types Functions References
Inhibitors related to the YAP phase seperation process EVG Disrupt the LLPS of the SRC-1 protein [66]
Verteporfin Sequester YAP in the cytoplasm and disrupt the formation of YAP-containing liquid droplets in cancer cells [63]
Peptidomimetics Disrupt the interaction between YAP and the transcriptional co-activator TEAD [53]
YAP-Tead interaction inhibitors Disrupt the interaction between YAP and the transcriptional co-activator TEAD [53]
Inhibitors related to the EGFR phase seperation process SHP099 SHP2 inhibitor [57]
Drugs affecting the process of LLPS 1,6-Hexanediol Disrupt the LLPS process of various proteins [25]
Delivery systems Liposomes Encapsulate a variety of drugs and other therapeutic agents [64]