Table 2.
Examples of advances in LLPS-based resistance against lung cancer
| Targets | Types | Functions | References |
|---|---|---|---|
| Inhibitors related to the YAP phase seperation process | EVG | Disrupt the LLPS of the SRC-1 protein | [66] |
| Verteporfin | Sequester YAP in the cytoplasm and disrupt the formation of YAP-containing liquid droplets in cancer cells | [63] | |
| Peptidomimetics | Disrupt the interaction between YAP and the transcriptional co-activator TEAD | [53] | |
| YAP-Tead interaction inhibitors | Disrupt the interaction between YAP and the transcriptional co-activator TEAD | [53] | |
| Inhibitors related to the EGFR phase seperation process | SHP099 | SHP2 inhibitor | [57] |
| Drugs affecting the process of LLPS | 1,6-Hexanediol | Disrupt the LLPS process of various proteins | [25] |
| Delivery systems | Liposomes | Encapsulate a variety of drugs and other therapeutic agents | [64] |