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. 2023 Aug 14;21:203. doi: 10.1186/s12964-023-01193-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — PECAM-1 defection and internalization enhanced the nuclear localization of β-catenin. a, b Localizations of PECAM-1 and β-catenin were observed after PECAM-1 siRNA treatment by immunofluorescence method under HG and SNs conditions, respectively. White arrows show the nuclear β-catenin; Yellow arrow heads show β-catenin in the membrane; White arrow heads show the colocation of PECAM-1 and β-catenin around the nucleus. c, d Total and phosphorylated β-catenin (Ser33) (a type to induce its degradation) were evaluated after PECAM-1 siRNA treatment by western blotting under HG and SNs conditions, respectively. The samples derive from the same experiment and that blots were processed in parallel. Data are means ± S.E.M. and analyzed using one-way ANOVA followed by Tukey’s multiple comparisons test. **p < 0.01, ****p < 0.0001