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. Author manuscript; available in PMC: 2023 Aug 15.
Published in final edited form as: DNA Repair (Amst). 2021 Jun 2;105:103141. doi: 10.1016/j.dnarep.2021.103141

Figure 2.

Figure 2.

Mechanism of competing endogenous (ceRNA) functionality of HOTAIR. HOTAIR contains miRNA response elements (MREs) that can bind to various miRNAs, and can therefore sponge multiple different miRNAs. (B) When HOTAIR is upregulated, more miRNAs are bound by it, freeing the miRNA target genes from miRNA-mediated suppression and resulting in their increased expression.