Table 2.
Protective functions and proposed modes of action of HOTAIR in certain conditions and cell types.
| Condition or cell type | Role of HOTAIR | Proposed mechanism of action | REFs |
|---|---|---|---|
| Vascular smooth muscle cells | Protection of apoptotic and proliferative properties | Upregulation of PPARα via sponging miR-130b-3p | 90 |
| Intervertebral disc degeneration | Prevents apoptosis of nucleus pulposus cells | Downregulation of apoptosis-related genes (Notch signaling pathway) via sponging miR-34a-5p |
91, 92 |
| Acute myocardial infarction | Protective factor for cardiomyocytes and biomarker for human AMI | Suppression of miR-1 | 93 |
| Oxidatively stressed cardiomyocytes | Protection against cell injury | Sponging miR-125 | 94 |
| Rheumatoid arthritis | Anti-inflammatory effect on LPS-treated chondrocytes | Inhibition of NF-κB | 104 |