Table 4.

Down syndrome Alzheimer’s disease (AD-DS) and matched disomic Alzheimer’s disease (EOAD) and healthy ageing case details. Summary of case demographics information of human post-mortem cases from matched disomic healthy ageing, EOAD and AD-DS cases, including age at death, post-mortem-interval, APOE genotype and Braak Tangle Stage

	Healthy ageing	EOAD	AD-DS
Gender	4 Male, 6 Female	4 Male, 6 Female	4 Male, 6 Female
Age at death (years)	68.3 $\pm$ 5.72	60.8 $\pm$ 6.03	60.2 $\pm$ 6.25
Post-mortem interval (h)	32.86 $\pm$ 15.27	30.73 $\pm$ 18.88	38.40 $\pm$ 19.74
APOE genotype (number of individuals)	2/3, 2/4 (2), 3/3 (5), 3/4, 4/4 (2), unknown (1)	2/3, 2/4 (2), 3/3 (3), 3/4, 4/4 (5)	2/3, 2/4 (2), 3/3 (5), 3/4, 4/4 (3)
Braak Tangle Stage (Number of individuals)	Not staged (6) 0 (1), I (1), II (2)	V (1) VI (9)	Not staged (1) IV (1) V (2) VI (6)