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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Maturitas. 2022 Nov 4;168:13–19. doi: 10.1016/j.maturitas.2022.10.006

Figure 2:

Figure 2:

Hypothalamic-pituitary-adrenal (HPA) axis response to stress and inflammation.

As a response to stress CRH is produced at the hypothalamic level stimulating ACTH production in the pituitary, that in turn leads to increase release of cortisol from the adrenal glands. The HPA axis is also activated in response to inflammation both at the hypothalamic or the pituitary level. (Figure created in biorender.com)