Skip to main content
. 2021 Mar 24;1(3):155–164. doi: 10.1016/j.xrrt.2021.03.002

Table II.

Requisite criteria for diagnosis of hEDS.

1. Generalized joint hypermobility
  • a.

    Prepubertal and adolescent: Beighton ≥ 6

  • b.

    Pubertal men and women of age 50 yr and younger: Beighton ≥ 5

  • c.

    Men and women older than 50 yr: Beighton ≥ 4

2. At least two of the following features:
  • a.

    Systemic manifestations of a generalized connective tissue disease

  • b.

    Positive family history with 1+ first-degree relatives meeting criteria for hEDS

  • c.
    One or more of the following musculoskeletal complications:
    • i.
      Daily musculoskeletal pain in ≥2 limbs for at least 3 mo
    • ii.
      Chronic, widespread pain for at least 3 mo
    • iii.
      Recurrent atraumatic joint dislocations or frank joint instability, defined by 3+ atraumatic dislocations in a single joint or 2+ atraumatic dislocations in different joints at different times
3. All of the following features:
  • a.

    Absence of unusual skin fragility

  • b.

    Exclusion of other hertiable and acquired connective tissue disorders

  • c.

    Exclusion of alternative diagnoses that may also include hypermobile joints

hEDS, hypermobile-type Ehlers-Danlos syndrome.