Table 3.
Factors associated with LFS, OS and TRM following second transplants.
| i) Results from Univariate Cox Regression Models for Overall Survival | ||||||
|---|---|---|---|---|---|---|
| Parameter | Level | N Patients | N Deaths | Hazard Ratio | 95% Confidence Interval (HR) | P-Value |
| Donor | Same | 16 | 14 | ----- | ----- | 0.72 |
| Different | 15 | 13 | 0.87 | 0.40, 1.88 | ||
| Conditioning | Ablative | 11 | 9 | ----- | ----- | 0.25 |
| RIC | 20 | 18 | 1.59 | 0.71, 3.59 | ||
| Time to Progression From SCT1 | Per Month | 31 | 27 | 0.94 | 0.89, 1.00 | 0.05 |
| Disease at 2nd Transplant | No | 19 | 15 | ----- | ----- | 0.67 |
| Yes | 12 | 12 | 1.18 | 0.55, 2.54 | ||
| Time Between Transplants | Per Month | 31 | 27 | 0.95 | 0.90, 1.01 | 0.08 |
| Age | Per Year | 31 | 27 | 1.01 | 0.98, 1.05 | 0.49 |
| aGVHD | Yes | 31 | 27 | 1.75 | 0.71, 4.34 | 0.22 |
| Chronic Extensive GVHD | Yes | 31 | 27 | 1.30 | 0.36, 4.74 | 0.69 |
| ii) Results from Univariate Cox Regression Models for Progression Free Survival | ||||||
| Parameter | Level | N Patients | N Events (Progression/Death) | Hazard Ratio | 95% Confidence Interval (HR) | P-Value |
| Donor | Same | 16 | 14 | ----- | ----- | 0.84 |
| Different | 15 | 13 | 0.93 | 0.43, 2.00 | ||
| Conditioning | Ablative | 11 | 9 | ----- | ----- | 0.28 |
| RIC | 20 | 18 | 1.58 | 0.69, 3.60 | ||
| Time to Progression From SCT1 | Per Month | 31 | 27 | 0.93 | 0.88, 0.99 | 0.02 |
| Disease at 2nd Transplant | No | 19 | 15 | ----- | ----- | 0.18 |
| Yes | 12 | 12 | 1.69 | 0.78, 3.69 | ||
| Time Between Transplants | Per Month | 31 | 27 | 0.95 | 0.90, 0.9998 | 0.05 |
| Age | Per Year | 31 | 27 | 1.01 | 0.97, 1.04 | 0.72 |
| aGVHD | Yes | 31 | 8 | 2.19 | 0.88, 5.46 | 0.09 |
| Chronic Extensive GVHD | Yes | 31 | 5 | 2.42 | 0.32, 18.2 | 0.39 |
| iii) Results from Univariate Cox Regression Models for Treatment Related Mortality | ||||||
| Parameter | Level | N Patients | N Deaths | Hazard Ratio | 95% Confidence Interval (HR) | P-Value |
| Sibling/MUD Donor | Sibling | 19 | 8 | ----- | ----- | 0.56 |
| MUD | 10 | 3 | 0.55 | 0.14, 2.07 | ||
| Cord | 2 | 1 | 1.58 | 0.19, 12.9 | ||
| Donor | Same | 16 | 6 | ----- | ----- | 0.88 |
| Different | 15 | 6 | 1.09 | 0.35, 3.41 | ||
| Conditioning | Ablative | 11 | 4 | ----- | ----- | 0.58 |
| RIC | 20 | 8 | 1.41 | 0.42, 4.78 | ||
| Time to Progression From SCT1 | Per Month | 31 | 12 | 0.98 | 0.91, 1.06 | 0.65 |
| Time Between Transplants | Per Month | 31 | 12 | 0.99 | 0.92, 1.06 | 0.78 |
| Age | Per Year | 31 | 12 | 1.03 | 0.98, 1.09 | 0.27 |
| aGVHD | Yes | 31 | 12 | 2.99 | 0.80, 11.2 | 0.10 |
| Chronic Extensive GVHD | Yes | 31 | 12 | 1.03 | 0.06, 17.0 | 0.98 |
RIC= Reduced intensity conditioning, GVHD= Graft versus host disease, MUD: matched unrelated donor.
--- represents reference group